The urban setting of America is filled with lost people. People who struggle with addictions, unemployment, homelessness, and hopelessness. Intercultural missionaries set up food distribution centers and provide the resources and spiritual guidance needed to bring hope and light to the inner-city areas of America. 

Over twenty-three million Americans have trouble seeing. even with corrective lenses, or are unable to see at all. The Assemblies of God is one of the few evangelical organizations to provide Bible-based Braille and audio literature for the blind through Center for the Blind.

Over thirty million Americans age twelve and older have some hearing loss in both ears, with American Sign Language the primary language tool for approximately five hundred thousand people.

Up to 300,000 American minors are lured into the commercial sex trade annually, and thousands more victims are brought into the country with the promise of jobs. U.S. missionaries raise awareness, are actively involved in rescue efforts, and serve in recovery homes.

The world is coming to the United States through refugee resettlement and immigration. Intercultural missionaries reach out through language classes, cultural adaptation, training local churches, and assisting ethnic pastors to reach their community.

Over five million Jewish people live in the United States, second only to Israel in total Jewish population. Our missionaries and ministries to Jewish people are committed to reaching them with the good news of Jesus the Messiah.

Islam is the fastest-growing major religion in the world and one of the fastest growing in the United States. Although working among Muslim populations can be very sensitive, many are open to the truth about Jesus, and our missionaries are making a difference!

Several Native Alaskan people groups follow ethnic religions. Weather, rough terrain, and the sheer number of square miles create an enormous task, but missionaries are working to take the gospel to even the most inaccessible places and to train indigenous pastors.

It is estimated that up to 80 percent of Native Americans will die of unnatural causes related to violence, poverty, or addiction. Intercultural missionaries bring biblical truth and hope to communities and reservations through Bible colleges and leadership programs.

About sixty million Americans live with some sort of disability, and 80 percent of those do not regularly attend church. Intercultural missionaries help churches become more disability friendly and provide support services and summer camps for people with disabilities and their families.